Award details

Molecular analysis of the role of the tachykinins in pain reward and anxiety

Reference	NEU15440
Principal Investigator / Supervisor	Professor Stephen Hunt
Co-Investigators / Co-Supervisors	Professor John Quinn
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	213,960
Status	Completed
Type	Research Grant
Start date	09/07/2001
End date	09/06/2005
Duration	47 months

Abstract

The substance P (NK1) receptor is important in pain, anxiety and reward behaviours. Good receptor antagonists are not available for mice and although the NK1 receptor is widely expressed in the CNS, the areas modulating these different behaviours are unclear. We propose therefore a molecular and behavioural analysis using over-expression of the human NK1 (hNK1) gene from its own promoter in a bacterial artificial chromosome construct. We will i) replace the mouse NK1 receptor by the hNK1 receptor. ii) Over-express the hNK1 receptor gene to assess behavioural changes. iii) Flank exon 2 of the hNK1 gene with lox-P sites prior to transgenic delivery in NK1 null mice to allow targeted deletion of the hNK1 receptor. (Joint with grant 15/NEU15439).

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

NEU15439 Molecular analysis of the role of the tachykinins in pain reward and anxiety

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