Award details

Molecular analysis of the role of the tachykinins in pain reward and anxiety

Reference	NEU15439
Principal Investigator / Supervisor	Professor John Quinn
Co-Investigators / Co-Supervisors	Professor Stephen Hunt
Institution	University of Liverpool
Department	Human Anatomy and Cell Biology
Funding type	Research
Value (£)	290,564
Status	Completed
Type	Research Grant
Start date	01/01/2002
End date	01/01/2006
Duration	48 months

Abstract

The substance P (NK1) receptor is important in pain, anxiety and reward behaviours. Good receptor antagonists are not available for mice and although the NK1 receptor is widely expressed in the CNS, the areas modulating these different behaviours are unclear. We propose therefore a molecular and behavioural analysis using over-expression of the human NK1 (hNK1) gene from its own promoter in a bacterial artificial chromosome construct. We will i) replace the mouse NK1 receptor by the hNK1 receptor. ii) Over-express the hNK1 receptor gene to assess behavioural changes. iii) Flank exon 2 of the hNK1 gene with lox-P sites prior to transgenic delivery in NK1 null mice to allow targeted deletion of the hNK1 receptor. (Joint with grant 31/NEU15440).

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Neurone (NEU) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

NEU15440 Molecular analysis of the role of the tachykinins in pain reward and anxiety

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search