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Novel DNA metallation reactions
Reference
MOL04601
Principal Investigator / Supervisor
Professor Peter Sadler
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
93,211
Status
Completed
Type
Research Grant
Start date
05/07/1995
End date
31/12/1997
Duration
30 months
Abstract
A novel series of square-planar metal complexes (e.g. Pt(II) and Pd(II)) will be prepared which can metallate DNA via chelate ring-opening reactions. The formation of mono- and bi-functional DNA adducts and their recognition by high-mobility-group proteins will be studied. The work may lead to new classes of drugs with unique mechanisms of action and be of value in antisense technology.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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