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Award details
Design and synthesis of inhibitors of carbohydrate-protein interactions
Reference
MOL04547
Principal Investigator / Supervisor
Professor Steve Homans
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
123,914
Status
Completed
Type
Research Grant
Start date
27/11/1995
End date
27/11/1998
Duration
36 months
Abstract
The overall aim of this programme is a 'proof of principle' in the design of novel carbohydrate ligands as candidate lead drug molecules effective against certain bacterial diseases such as cholera, by exploiting the fact that the host-pathogen interaction depends upon specific oligosaccharide-protein recognition phenomena. This will involve the rational design of drug molecules using high-resolution structural information on the carbohydrate-protein interaction in combination with molecular modelling and computational chemistry, together with screening for activity by biochemical assay and isotope-edited NMR experiments.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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