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Searching the determinants of myeloid tropism and genetic resistance to monocyte transformation by avian leukosis virus subgroup J

Reference	LKS18173
Principal Investigator / Supervisor	Professor Venugopal Nair
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	Div of Immunology Compton
Funding type	Research
Value (£)	173,068
Status	Completed
Type	Research Grant
Start date	15/02/2003
End date	14/08/2006
Duration	42 months

Abstract

Avian leukosis virus subgroup J (ALV-J) is a new avian pathogen that causes widespread losses to the poultry industry worldwide. The unique features of this virus include its tropism for myeloid lineage of cells and the wide host range of infection among all the chicken lines. However, different lines of birds vary in their susceptibility to development of tumours suggesting the existence of genetic resistance to tumour development. We have demonstrated that env gene is an important determinant for the cell type-specific tropism of oncogenicity. This project is aimed to identify the specific receptor for ALV-J and examine the correlation between the distribution of ALV subgroup-specific receptors and cell lineage-specific oncogenicity. Furthermore, the use of in vitro monocyte transformation assay as a tool to study genetic resistance to oncogenesis will also be examined.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Animal Sciences Committee (ASL) [1996-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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