Award details

(A) Cell stretcher for studies of mechanosensitive signalling and cellular responses to mechanical strain

Reference	JRE10822
Principal Investigator / Supervisor	Professor Birgitte Lane
Co-Investigators / Co-Supervisors	Professor Hari Hundal, Professor Christopher Proud, Dr Peter Taylor
Institution	University of Dundee
Department	College of Life Sciences
Funding type	Research
Value (£)	13,100
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	01/07/1999
Duration	6 months

Abstract

The responses and tolerance of cells to static or cyclic mechanical loading in vivo underlie several important physiological and pathological processes, but the lack of appropriate and reproducible in vitro (cell-culture) methods for studying these phenomena has hindered detailed investigation at cellular and molecular levels and hindered progress in elucidation of the mechanisms involved. The new Flexercell FX3000 strain unit provides a controlled, mechanically-active environment for cultured cells, enabling studies designed to develop a detailed understanding of mechanosensitive processes and signalling mechanisms in normal and genetically-altered (or-damaged) cells. These include the following specific projects:- (i) The role of keratins in determining the physical properties of epithelial cells (Professor B E B Lane); (ii) Integrin-mediated signalling in the anabolic response of skeletal muscle to stretch (Dr P M Taylor); (iii) Effects of stretch on glucose transport and 5HT2A receptor expression in skeletal muscle (Dr H S Hundal); (iv) Signalling pathways involved in hypertrophy and the regulation of protein synthesis in cardiomyocytes (Professor C G Proud). The knowledge gained is likely to be of direct relevance for design and improvement of therapy for clinical conditions including insulin-resistance, skeletal-muscle wasting, cardiac hypertrophy and skin fragility disorders.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1998 (JE3) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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