Award details

Laser microdissection microscope for Institute for Animal Health Pirbright

Reference	JE616422
Principal Investigator / Supervisor	Dr Penelope Powell
Co-Investigators / Co-Supervisors	Professor Soren Alexandersen, Prof. Tom Wileman
Institution	The Pirbright Institute
Department	Div of Immunology Pirbright
Funding type	Research
Value (£)	51,644
Status	Completed
Type	Research Grant
Start date	21/06/2002
End date	21/06/2003
Duration	12 months

Abstract

The remit of the IAH is to understand host-pathogen interactions at a molecular level. To do this we have to be able to analyse gene expression in cells infected with pathogens and laser capture microdissection is the method of choice. This proposal justifies purchase of a laser capture microdissection system to be sited at the recently established Bioimaging Unit at the Pirbright Laboratory. The microscope will be used to study a broad range of pathogens of economic importance to UK and of threat to the UK food chain. These range from the complex protozoan Eimeria through bacteria such as Salmonella and bovine tuberculosis to the simple picornavirus responsible for Foot and Mouse disease. In each case, the effects of pathogens on host gene expression at sites of pathology and persistence will be characterised at a molecular level. The microscope will also be used to determine how changes in virus genome in vivo correlate with persistence and virulence.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2001 (JE6) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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