Award details

(I) New transmission electron microscope for Institute of Animal Health

Reference	JE514377
Principal Investigator / Supervisor	Prof. Tom Wileman
Co-Investigators / Co-Supervisors	Dr Paul Monaghan
Institution	The Pirbright Institute
Department	Div of Microbiology Compton
Funding type	Research
Value (£)	178,880
Status	Completed
Type	Research Grant
Start date	01/01/2002
End date	01/07/2002
Duration	6 months

Abstract

The current goal of the IAH is to understand host-pathogen interactions at a molecular level. Many important proteins have been sequenced, purified and used to generate antibodies. Understanding how and where these proteins function in the host requires the sub-cellular localisation of both host and pathogen proteins. To undertake this work, there is an urgent need for improvements of the Institute's electron microscopes. We request one TEM to replace two current TEMs. One is 25 years old and the other is 15 years old and inappropriate for our present and future needs. The new microscope will be sited at Pirbright in the Bioimaging unit which has been recently established. Experienced staff have been recruited and the unit is fully equipped for specimen preparation. The unit will underpin the science of the Institute of all three sites. This application details nine projects where cryoTEM or immunolabeling will be essential to their progress and covers a protozoan, bacteria and several virus projects. In each case, virulence factors have been characterised at a molecular level. Understanding the cell biology of how and where they act in the host cell requires high-resolution localisation by electron microscopy. This application justifies the purchase of a new TEM.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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