Award details

(A) A cryoprobe for a 500MHz NMR spectrometer

Reference	JE514287
Principal Investigator / Supervisor	Professor Michael Williamson
Co-Investigators / Co-Supervisors	Professor Jon Waltho
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	100,000
Status	Completed
Type	Research Grant
Start date	20/11/2001
End date	20/05/2002
Duration	6 months

Abstract

This proposal is for a cryoprobe to be fitted to our existing Bruker 500 MHz NMR spectrometer. The cryoprobe gives much better sensitivity than existing technology, and converts a 500 MHz instrument into a machine with the sensitivity of a 900 MHz spectrometer at a fraction (approximately 7%) of the cost, thus enabling studies of biomolecules that are marginally soluble, stable or available. The cryoprobe will be used to investigate biomolecular structure and function in a range of competitive areas including proteins involved in infectious diseases, prion and amyloid diseases, and cancer; carbohydrate recognition; salivary proteins and their interactions with dietary components; developmental control; and protein folding and misfolding. The equipment will expand the collaborative use of high-field NMR in the Krebs Institute at the University of Sheffield, and throughout the North of England in the North of England Structural Biology Centre (NESBIC).

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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