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Award details
(A) Analysis of transgenic plants and micro-organisms with improved nutraceutical profiles
Reference
JE412688
Principal Investigator / Supervisor
Professor Peter Bramley
Co-Investigators /
Co-Supervisors
Professor Paul Fraser
Institution
Royal Holloway, Univ of London
Department
Biological Sciences
Funding type
Research
Value (£)
14,797
Status
Completed
Type
Research Grant
Start date
01/04/2000
End date
01/10/2000
Duration
6 months
Abstract
Improving the isoprenoid content of plants and micro-organisms has a variety of potential health-related biotechnological applications. This proposal aims to characterise the phytosterol/sterol contents of transgenic plants and yeasts expressing genes involved in the mevalonate pathway. Non-mevalonate pathway intermediates will be analysed in transgenic and mutant plants and micro-organisms expressing genes involved in the formation of isoprenoids via the mevalonate-independent pathway. Metabolite profiling of T-DNA Arabidopsis thaliana collections will be performed to aid functional identification of genes. Metabolome analysis will be carried out on a number of transgenics and natural mutants to identify unintended effects relating to GMO (Genetically Modified Organisms) safety aspects. These analyses require dedicated Gas Chromatography separations to complement the applicants' existing HPLC expertise.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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