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Award details
(A) CD spectropolarimetry of proteins
Reference
JE412668
Principal Investigator / Supervisor
Professor Jon Waltho
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
100,856
Status
Completed
Type
Research Grant
Start date
07/07/2000
End date
07/01/2001
Duration
6 months
Abstract
The objectives are to measure structural changes in proteins which span a wide variety of projects within the Krebs Institute, from conformational transitions measured on protein folding, proteins mis-folding to disease causing amyloidogenic forms, enzyme catalysis and ligand binding. This award will support the following studies: 1). protein folding and amyloidogenesis of cystatins, human prion proteins and PGK; 2). structure and function of light harvesting complexes in plants; 3a). the enzymology of the biosynthetic pathways for chlorophylls and carotenoid pigments, and 3b). the assembly, structure and function of light harvesting (LH) complexes; 4). conformational transitions that accompany DNA recognition and catalysis by DNA methyltransferases; 5). bacterial respiration; and 6). oxygen-regulated gene expression and haemolysin activity and export.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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