Award details

Function regulation and structure of the utrophin ZZ domain

Reference	ICR07596
Principal Investigator / Supervisor	Professor Steve Winder
Co-Investigators / Co-Supervisors	Professor Paul Barlow
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	158,997
Status	Completed
Type	Research Grant
Start date	01/08/1997
End date	01/12/2000
Duration	40 months

Abstract

Utrophins are ubiquitous and essential components of the eukaryote submembranous cytoskeleton found in all species studied, from insects to man. Utrophin functions as a link between the actin cytoskeleton and via a complex of membrane proteins, through to the extracellular matrix. We propose to determine the function, regulation and tertiary structure of the utrophin ZZ domain, a novel type of zinc finger involved in protein-protein interactions. The basis of this zinc finger protein-protein interaction, target molecules it interacts with and it's potential regulation by calmodulin will be elucidated using molecular, biochemical and NMR spectroscopy techniques.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integration of Cellular Responses (ICR) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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