Award details

Novel dendrimers for gene transfer

Reference	GTH12564
Principal Investigator / Supervisor	Dr Lance Twyman
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Chemistry
Funding type	Research
Value (£)	143,796
Status	Completed
Type	Research Grant
Start date	01/05/2000
End date	01/05/2003
Duration	36 months

Abstract

In this study we will develop a new range of non-viral vectors for gene transfer, based on branched dendrimer molecules. We will investigate the potential for targeting dendrimers using ligands, peptides and antibodies, and also to evaluate two new types of molecule (dendron and unsymmetric dendrimers), optimising features of the design of these molecules such as their geometry, flexibility and internal free space. The project offers the possibility of new generic technologies for gene transfer, including targeted gene delivery. These will be of benefit not only in the context of gene therapy, but also for experimental testing of novel gene constructs prior to developing transgenic animals, for example for xenotransplantation. (Joint 60/GTH12562)

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

GTH12562 Novel dendrimers for gene transfer

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