Award details

Novel dendrimers for gene transfer

Reference	GTH12562
Principal Investigator / Supervisor	Professor Andrew George
Co-Investigators / Co-Supervisors
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	165,404
Status	Completed
Type	Research Grant
Start date	01/07/2000
End date	17/11/2003
Duration	41 months

Abstract

In this study we will develop a new range of non-viral vectors for gene transfer, based on branched dendrimer molecules. We will investigate the potential for targeting dendrimers using ligands, peptides and antibodies, also evaluate two new types of molecule (dendron and unsymmetric dendrimers), optimising features of the design of these molecules such as their geometry, flexibility and internal free space. This project offers the possibility of new generic technologies for gene transfer, including targeted gene delivery. These will be of benefit not only in the context of gene therapy, but also for experimental testing of novel gene constructs prior to developing transgenic animals, for example for xenotransplantation. (Joint grant with 89/GTH12564)

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

GTH12564 Novel dendrimers for gene transfer

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