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Development and evolution of anteroposterior asymmetry in the fish inner ear

Reference	G19428
Principal Investigator / Supervisor	Professor Tanya Whitfield
Co-Investigators / Co-Supervisors	Dr Katherine Hammond
Institution	University of Sheffield
Department	Centre for Development Genetics
Funding type	Research
Value (£)	229,387
Status	Completed
Type	Research Grant
Start date	01/08/2003
End date	31/12/2006
Duration	41 months

Abstract

We aim to understand how asymmetries about the anteroposterior (AP) axis of the gnathostome inner ear are specified in the embryo, and how they have evolved. We will compare the highly asymmetric ears of gnathostomes (dogfish, zebrafish) with those of agnathans (hagfish, lamprey), which are nearly symmetric about the AP axis, and represent primitive forms. We will characterise the normal development of hagfish, lamprey and dogfish ears and compare expression of lamprey and dogfish homologues of zebrafish genes expressed asymmetrically about the otic AP axis. We will focus on Hedgehog pathway genes, which we have shown to be required for zebrafish posterior otic identity. Functional analysis of key genes will be performed using zebrafish.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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