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Molecular genetic analysis of gamma-glutamylcysteine synthetase in Drosophila melanogaster with respect to ageing

ReferenceG15091
Principal Investigator / Supervisor Dr Lesley McLellan
Co-Investigators /
Co-Supervisors
Institution University of Dundee
DepartmentBiomedical Research Centre
Funding typeResearch
Value (£) 177,176
StatusCompleted
TypeResearch Grant
Start date 01/10/2001
End date 01/10/2004
Duration36 months

Abstract

A growing body of evidence exists to suggest that reactive oxygen species (ROS) impact on the life span of multicellular organisms, by causing the accumulation of damaged macromolecules in post-mitotic cells. The aim of this project is to test the hypothesis that the capacity to synthesise the endogenous antioxidant glutathione has a major influence on life span by protecting against the deleterious effects of ROS. We propose to manipulate the activity of the rate-limiting enzyme in glutathione biosynthesis, gamma- glutamylcysteine synthetase, in the fruit fly Drosophila to create animals with both increased and reduced capacity to synthesise glutathione. The effects on resistance to oxidative stress and life span will be examined. (Joint with grant 108/G15090).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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