Award details

Molecular genetic analysis of gamma-glutamylcysteine synthetase in Drosophila melanogaster with respect to ageing

Reference	G15090
Principal Investigator / Supervisor	Dr Robert Saunders
Co-Investigators / Co-Supervisors
Institution	Open University
Department	Life, Health & Chemical Sciences
Funding type	Research
Value (£)	256,268
Status	Completed
Type	Research Grant
Start date	01/10/2001
End date	01/10/2004
Duration	36 months

Abstract

A growing body of evidence exists to suggest that reactive oxygen species (ROS) impact on the life span of multicellular organisms, by causing the accumulation of damaged macromolecules in post-mitotic cells. The aim of this project is to test the hypothesis that the capacity to synthesise the endogenous antioxidant glutathione has a major influence on life span by protecting against the deleterious effects of ROS. We propose to manipulate the activity of the rate-limiting enzyme in glutathione biosynthesis, gamma- glutamylcysteine synthetase, in the fruit fly Drosophila to create animals with both increased and reduced capacity to synthesise glutathione. The effects on resistance to oxidative stress and life span will be examined. (Joint with grant 94/G15091).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G15091 Molecular genetic analysis of gamma-glutamylcysteine synthetase in Drosophila melanogaster with respect to ageing

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