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An investigation of dosage compensation in chickens
Reference
G13035
Principal Investigator / Supervisor
Dr Heather McQueen
Co-Investigators /
Co-Supervisors
Professor Adrian Bird
,
Dr Michael Clinton
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
153,724
Status
Completed
Type
Research Grant
Start date
01/10/2000
End date
27/04/2004
Duration
43 months
Abstract
Male birds have twice the dose of all Z-linked genes compared to ZW females. Preliminary experiments show equal expression levels of two Z-linked genes in male and female embryos and, for the first time, suggest avian dosage compensation. We aim to investigate the extent and mechanism of this dosage compensation in chickens. Firstly we will study expression levels of previously mapped Z genes in male and female chick embryos and we will then determine chromosomal organisation of genes with and without compensation. Secondly we aim to determine whether expression of compensated genes is from one or both male Z alleles and to look for differences between male and female Z chromosomes in terms of promoter methylation and chromatin structure.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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