Award details

Comparative genomics of the genus Saccharomyces

Reference	G10414
Principal Investigator / Supervisor	Professor Stephen Oliver
Co-Investigators / Co-Supervisors	Professor Edward Louis
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	210,211
Status	Completed
Type	Research Grant
Start date	08/06/1999
End date	30/08/2002
Duration	39 months

Abstract

The genomes of members of the Saccharomyces senso stricto group of yeasts will be compared with one another, and with those of Saccharomyces castellii and Kluyveromyces lactis, in order to assess the role that reciprocal translocation has played in speciation within this group of yeasts. The phylogenetic relationships between these yeasts will be assessed using comparisons between both single-copy and repeated genes on nuclear chromosomes, the nuclear extrachromosome 2 micrometers, and the cytoplasmic extrachromosome mtDNA. The hypothesis that the S. cerevisiae genome underwent a complete duplication during its evolution will be tested, and genome rearrangements associated with apparently virulent clinical isolates of Saccharomyces assessed. (Joint with grant G10415).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G10415 Comparative genomics of the genus Saccharomyces

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