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Metallothionein as a zinc chaperone: SmtA-DnaG interactions

Reference	G10320
Principal Investigator / Supervisor	Professor Nigel Robinson
Co-Investigators / Co-Supervisors	Professor Peter Sadler
Institution	Newcastle University
Department	School of Cell and Molecular Biosciences
Funding type	Research
Value (£)	147,680
Status	Completed
Type	Research Grant
Start date	01/04/1999
End date	01/04/2002
Duration	36 months

Abstract

The cellular importance of zinc is evident. However it is not clear how zinc 'reaches' proteins, and it is unclear whether the delivery of zinc ever regulates protein activity. Proteins that deliver copper, copper chaperones, have recently been described and it has been proposed that zinc-metallothioneins may (be at least one of the proteins that) perform analogous roles for zinc. We will investigate interactions between prokaryotic metallothionein, SmtA, and a most likely zinc-acceptor, DNA-primase. The role of a eukaryotic style zinc-finger in DNA-primase will be determined in Synechococcus PCC7942.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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