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Metallothionein as a zinc chaperone: SmtA-DnaG interactions

Principal Investigator / Supervisor Professor Nigel Robinson
Co-Investigators /
Professor Peter Sadler
Institution Newcastle University
DepartmentSchool of Cell and Molecular Biosciences
Funding typeResearch
Value (£) 147,680
TypeResearch Grant
Start date 01/04/1999
End date 01/04/2002
Duration36 months


The cellular importance of zinc is evident. However it is not clear how zinc 'reaches' proteins, and it is unclear whether the delivery of zinc ever regulates protein activity. Proteins that deliver copper, copper chaperones, have recently been described and it has been proposed that zinc-metallothioneins may (be at least one of the proteins that) perform analogous roles for zinc. We will investigate interactions between prokaryotic metallothionein, SmtA, and a most likely zinc-acceptor, DNA-primase. The role of a eukaryotic style zinc-finger in DNA-primase will be determined in Synechococcus PCC7942.


Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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