Award details

A novel approach to the analysis of human genomic variation investigating heterogeneity of both mutation and recombination.

Reference	G09617
Principal Investigator / Supervisor	Professor David Balding
Co-Investigators / Co-Supervisors	Dr John Whittaker
Institution	University of Reading
Department	Applied Statistics
Funding type	Research
Value (£)	113,212
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	31/01/2002
Duration	40 months

Abstract

Using new molecular and statistical approaches we will examine 8 Mb of Xq to investigate heterogeneity of mutation and recombination and develop new models for the study of human genome diversity. Starting with six 1.5kb segments in each of 40 cosmids at intervals of 200 kb and a male population, variation will be examined in haplotype configuration. This will be extended to locate potential recombination hotspots and examine populations thought to have been subject to strong founder effects and genetic drift. Techniques for a single genealogical tree will be extended to analyse simultaneously several trees representing genealogies at distinct haplotype locations. The distribution of mutations and recombinations and the depth of genealogies along the 8 Mb haplotypes will be characterised. (Joint with grant 28/G09617).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G09616 A novel approach to the analysis of human genome variations investigating heterogeneity of both mutation and recombination.

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