Award details

A novel approach to the analysis of human genome variations investigating heterogeneity of both mutation and recombination.

Reference	G09616
Principal Investigator / Supervisor	Professor Francesco Giannelli
Co-Investigators / Co-Supervisors	Dr Peter Green
Institution	King's College London
Department	Division of Medical & Molecular Genetics
Funding type	Research
Value (£)	177,013
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	01/10/2001
Duration	36 months

Abstract

Using new molecular and statistical approaches we will examine 8 Mb of Xq to investigate heterogeneity of mutation and recombination and develop new models for the study of human genome diversity. Starting with six 1.5kb segments in each of 40 cosmids at intervals of 200 kb and a male population, variation will be examined in haplotype configuration. This will be extended to locate recombination hotspots and examine populations characterised by strong founder effects and genetic drift. Techniques for a single genealogical tree will be extended to analyse simultaneously several trees representing genealogies at distinct haplotype locations. The distribution of mutations and recombinations and the depth of genealogies along the 8 Mb haplotypes will be defined. (Joint with grant 45/G09617).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G09617 A novel approach to the analysis of human genomic variation investigating heterogeneity of both mutation and recombination.

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