Award details

Eukaryote gene number estimation by a genomic sequence sampling strategy

Reference	G09314
Principal Investigator / Supervisor	Professor Adrian Bird
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	Inst of Cell and Molecular Biology
Funding type	Research
Value (£)	172,417
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	01/10/2001
Duration	36 months

Abstract

We propose to employ a novel genomic sequence sampling strategy to estimate the gene number of several organisms. The strategy involves the generation of DNA sequence from random genomic fragments, followed by the application of sequence analysis and database homology tools to assess its protein-coding potential. We will study two organisms in the first instance: the lancelet, which is the most vertebrate-like invertebrate, and the lamprey, which is grouped with the most primitive vertebrates. As part of the same project, we also wish to determine gene number in a member of arguably the most complex invertebrate group, the cephalopods. Reliable estimates for all three species will allow us to test hypotheses about the nature and significance of the transition from invertebrates to vertebrates.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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