Award details

Maintenance of liver cell phenotype: characterisation of signalling factors which regulate differentiation of isolated hepatocytes

Reference	G06311
Principal Investigator / Supervisor	Professor Alan Dickson
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	218,850
Status	Completed
Type	Research Grant
Start date	01/09/1996
End date	01/10/1999
Duration	37 months

Abstract

Isolated hepatocytes offer a valuable experimental system of direct relevance to the biopharmaceuticals industry. Events triggered by hepatocyte isolation initiate loss of liver phenotype and limits the use of cells to short-term experiments. Using rodent liver cells, this application will define the signalling factors which are activated by isolation procedures and (i) how they initiate loss of valuable liver-specific functions and (ii) how they are influenced by cell-matrix interactions. This study will serve as a paradigm for understanding loss of differentiated function in other valuable primary cell preparations from human and rodent sources and will define generic strategies to prevent loss of differentiated function.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search