Award details

The structure and assembly of retrotransposon virus-like particles

Reference	G06016
Principal Investigator / Supervisor	Dr A Kingsman
Co-Investigators / Co-Supervisors	Professor Susan Kingsman
Institution	University of Oxford
Department	Biochemistry
Funding type	Research
Value (£)	84,260
Status	Completed
Type	Research Grant
Start date	01/10/1996
End date	01/10/1997
Duration	12 months

Abstract

The virus-like particles (VLPs) produced by the yeast Ty element are central to the mechanism of retrotransposition, they are structural and functional analogues of retrovirus cores, they are being used as antigen presentation systems to elicit both cellular and humoral responses in man and animals and they are models for novel, highly flexible assembly pathways. We aim to analyse the structure of Ty-VLPs using a combination of mutagenesis, protein chemistry, in vitro transposition essays, and a variety of biophysical techniques. This study will provide the most detailed model for a retro-particle to date with implications for our understanding of retroviral assembly, vaccine design and retro-element mediated gene delivery.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

B05159 The structure and assembly of retrotransposon virus-like particles

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