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CpG islands as markers for genome analysis of livestock
Reference
G02381
Principal Investigator / Supervisor
Professor Adrian Bird
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
137,355
Status
Completed
Type
Research Grant
Start date
02/03/1995
End date
21/10/1998
Duration
43 months
Abstract
CpG islands, which are associated with about 60% of genes in man, represent markers for the expressed portions of complex genomes. Recently developed methods to create genomic libraries enriched for CpG islands will be used to establish such libraries for pigs, cattle and chickens and a chromosome-specific CpG island library for porcine chromosome 6. CpG island clones, especially those from the chromosome 6 library, will be mapped to large fragment genomic clones in YAC or P1 vectors. Genetic markers will be developed from individual CpG island clones and mapped by linkage analysis. Therefore this project will contribute to the identification of genes and the development of both physical and genetic (linkage) gene maps of livestock.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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