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Antioxidant response and resistance to oxidative stress in Drosophila with respect to ageing

ReferenceERA16290
Principal Investigator / Supervisor Dr Lesley McLellan
Co-Investigators /
Co-Supervisors
Institution University of Dundee
DepartmentBiomedical Research Centre
Funding typeResearch
Value (£) 180,736
StatusCompleted
TypeResearch Grant
Start date 01/04/2002
End date 31/05/2006
Duration50 months

Abstract

Oxidative stress has been proposed to be a major causal factor of ageing by mediating an accumulation of oxidative damage to cellular macromolecules. We wish to test the hypothesis that antioxidant proteins involved in adaptive response and resistance to oxidative stress (specifically caused by thiol-reactive agents) impact on life span in Drosophila. Using a combined genomic/proteomic approach, we aim to identify antioxidant proteins which are differentially regulated upon exposure to glutathione depleting agents, and contribute to resistance to the same agents. Candidate genes will be subject to over-expression or mutation and effects on resistance to oxidative stress and life span examined. In addition, known thiol antioxidant proteins will be tested for their ability to affect life span and oxidative stress resistance. (Joint with grant 104/16289).

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Experimental Research on Ageing (ERA) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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