Award details

Antioxidant Response and resistance to oxidative stress in Drosophila with respect to ageing

Reference	ERA16289
Principal Investigator / Supervisor	Dr Robert Saunders
Co-Investigators / Co-Supervisors
Institution	Open University
Department	Life, Health & Chemical Sciences
Funding type	Research
Value (£)	215,036
Status	Completed
Type	Research Grant
Start date	17/06/2002
End date	17/06/2005
Duration	36 months

Abstract

Oxidative stress has been proposed to be a major causal factor of ageing by mediating an accumulation of oxidative damage to cellular macromolecules. We wish to test the hypothesis that antioxidant proteins involved in adaptive response and resistance to oxidative stress (specifically caused by thiol-reactive agents) impact on life span in Drosophila. Using a combined genomic/proteomic approach, we aim to identify antioxidant proteins which are differentially regulated upon exposure to glutathione depleting agents, and contribute to resistance to the same agents. Candidate genes will be subject to over-expression or mutation and effects on resistance to oxidative stress and life span examined. In addition, known thiol antioxidant proteins will be tested for their ability to affect life span and oxidative stress resistance. (Joint with grant 94/ERA16290).

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Experimental Research on Ageing (ERA) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

ERA16290 Antioxidant response and resistance to oxidative stress in Drosophila with respect to ageing

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