Award details

cDNA viral display and small molecule immobilization chemistry : discovery technologies for ligand-receptor partnerships

Reference	EGM17690
Principal Investigator / Supervisor	Dr Andrew Clark
Co-Investigators / Co-Supervisors	Dr Andrew Marsh, Professor Paul Taylor
Institution	University of Warwick
Department	Chemistry
Funding type	Research
Value (£)	110,568
Status	Completed
Type	Research Grant
Start date	31/03/2003
End date	30/04/2005
Duration	25 months

Abstract

Relating sequence information to biological function is a huge challenge in the post-genomic era. We will develop technology that will allow rapid identification of proteins that bind to small-molecule ligands. The technology will consist of novel and generic approaches to ligand immobilisation chemistry and new cDNA display libraries that display all expressed proteins on the surface of eukaryotic and prokaryotic viruses, linked to their encoding cDNA. This will allow automated biopanning of display libraries against any ligand. Information on binding activities will lead directly to identification of receptor-ligand partnerships and to conclusions on gene function. (Joint with grants 17769 and 17791).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Manufacturing & New Post Tech (EGM) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

EGM17689 cDNA viral display and small molecule immobilization chemistry: discovery technologies for ligand-receptor partnerships

EGM17691 cDNA viral display and small molecule immobilization chemistry: discovery technologies for ligand-receptor partnerships

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