Award details

The road to drug discovery: structure-function studies of novel essential bacterial gene products

Reference	EGH16083
Principal Investigator / Supervisor	Professor Simon J. Foster
Co-Investigators / Co-Supervisors	Professor Peter Artymiuk, Dr Patrick Baker, Dr John Rafferty, Professor David Rice, Professor Jon Waltho, Professor Michael Williamson
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	740,068
Status	Completed
Type	Research Grant
Start date	01/06/2002
End date	30/11/2006
Duration	54 months

Abstract

Antibiotic resistant bacteria are a constant and increasing threat to human health. The proposed project will exploit genomics information from Bacillus subtilis, a model Gram-positive, to characterise new drug targets for the control of bacterial pathogens. A set of novel, putatively essential, gene products will be analysed by structure-function studies. The synergy of molecular physiology, biochemistry and structural biology will combine to analyse the set of novel essential genes. The interaction will enhance our understanding of the fundamental processes crucial for the life of bacteria and provide the basis for antimicrobial drug development by UK industry.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Healthcare, Pharmaceuticals (EGH) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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