BBSRC Portfolio Analyser

Award details

Exploiting genomics to make glycodisic bonds: Biocatalysis in vitro and metabolic engineering in vivo

ReferenceEGA16207
Principal Investigator / Supervisor Professor Harry Gilbert
Co-Investigators /
Co-Supervisors
Institution Newcastle University
DepartmentAgriculture Food and Rural Development
Funding typeResearch
Value (£) 220,568
StatusCompleted
TypeResearch Grant
Start date 01/09/2002
End date 01/09/2006
Duration48 months

Abstract

Five laboratories specialising in biology, chemistry and biotechnology will undertake a multidisciplinary programme to identify and evaluate plant and microbial glycosyltransferases (GTs) from the GT-1 and GT-4 multigene families. High throughput screens will identify substrates relevant to: 1). industrial feedstocks, 2). natural products used as food ingredients, 3). plant hormones and their analogues, and 4). xenobiotics, including organic pollutants and pesticides. Crystallographic analyses of these GTs and rational design together with forced protein evolution, will generate novel, improved biocatalysts. The utility of GTs for plant metabolic engineering in relation to agricultural traits, novel products and phytoremediation will be determined. (Joint with grants 87/EGA16205 and 12/EGA16206).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Exploiting Genomics: Agri, Food and Environment (EGA) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
terms and conditions of use (opens in new window)
export PDF file
back to list new search