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Exploiting genomics to make glycosidic bonds: Biocatalysis in vitro and metabolic engineering in vivo

ReferenceEGA16206
Principal Investigator / Supervisor Professor Robert Edwards
Co-Investigators /
Co-Supervisors		 Professor Benjamin Davis
Institution Durham University
DepartmentBiological and Biomedical Sciences
Funding typeResearch
Value (£) 255,256
StatusCompleted
TypeResearch Grant
Start date 01/10/2002
End date 28/02/2007
Duration53 months

Abstract

Five laboratories specialising in biology, chemistry and biotechnology will undertake a multidisciplinary programme to identify and evaluate plant and microbial glycosyltransferases (GTs) from the GT-1 and GT-4 multigene families. High throughput screens will identify substrates relevant to: 1). industrial feedstocks, 2). natural products used as food ingredients, 3). plant hormones and their analogues, and 4). xenobiotics, including organic pollutants and pesticides. Crystallographic analyses of these GTs and rational design together with forced protein evolution, will generate novel, improved biocatalysts. The utility of GTs for plant metabolic engineering in relation to agricultural traits, novel products and phytoremediation will be determined. (Joint with grants 87/EGA16205 and 13/EGA16207).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Exploiting Genomics: Agri, Food and Environment (EGA) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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