Award details

Drug delivery using nanoparticles assembled from novel functional biodegradable polymers

Reference	E19351
Principal Investigator / Supervisor	Professor Gillian Hutcheon
Co-Investigators / Co-Supervisors	Dr Sean Higgins
Institution	Liverpool John Moores University
Department	Pharmacy and Biomolecular Sciences
Funding type	Research
Value (£)	203,168
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	01/04/2006
Duration	36 months

Abstract

We have shown that biodegradable functional polymers can be readily synthesised enzymatically and modified with acyl chains and PEG groups. These copolymers can be assembled into nanoparticles incorporating significant amounts of drugs. This proposal will explore further backbone structures which can be synthesised enzymatically and a wider range of functional pendant groups and side chains. These novel functional polymers will be examined for their ability to form nanoparticles, to incorporate a wider range of drugs and control drug release. Drugs and biomolecules with varying physicochemical properties will be assessed. Promising drug delivery systems will be investigated in animal studies for biodistribution of both polymer and drug. (Joint with grant number 19350).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E19350 Drug delivery using nanoparticles assembled from novel functional biodegradable polymers

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