Award details

Drug delivery using nanoparticles assembled from novel functional biodegradable polymers

ReferenceE19351
Principal Investigator / Supervisor Professor Gillian Hutcheon
Co-Investigators /
Co-Supervisors
Dr Sean Higgins
Institution Liverpool John Moores University
DepartmentPharmacy and Biomolecular Sciences
Funding typeResearch
Value (£) 203,168
StatusCompleted
TypeResearch Grant
Start date 01/04/2003
End date 01/04/2006
Duration36 months

Abstract

We have shown that biodegradable functional polymers can be readily synthesised enzymatically and modified with acyl chains and PEG groups. These copolymers can be assembled into nanoparticles incorporating significant amounts of drugs. This proposal will explore further backbone structures which can be synthesised enzymatically and a wider range of functional pendant groups and side chains. These novel functional polymers will be examined for their ability to form nanoparticles, to incorporate a wider range of drugs and control drug release. Drugs and biomolecules with varying physicochemical properties will be assessed. Promising drug delivery systems will be investigated in animal studies for biodistribution of both polymer and drug. (Joint with grant number 19350).

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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