Award details

Drug delivery using nanoparticles assembled from novel functional biodegradable polymers

Reference	E19350
Principal Investigator / Supervisor	Professor Martin Garnett
Co-Investigators / Co-Supervisors	Dr Paraskevi Kallinteri
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	205,680
Status	Completed
Type	Research Grant
Start date	01/07/2003
End date	30/06/2006
Duration	36 months

Abstract

We have shown that biodegradable functional polymers can be readily synthesised enzymatically and modified with acyl chains and PEG groups. These copolymers can be assembled into nanoparticles incorporating significant amounts of drugs. This proposal will explore further backbone structures which can be synthesised enzymatically and a wider range of functional pendant groups and side chains. These novel functional polymers will be examined for their ability to form nanoparticles, to incorporate a wider range of drugs and control drug release. Drugs and biomolecules with varying physicochemical properties will be assessed. Promising drug delivery systems will be investigated in animal studies for biodistribution of both polymer and drug. (Joint with grant number 19351).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E19351 Drug delivery using nanoparticles assembled from novel functional biodegradable polymers

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