Award details

Non-viral gene delivery system for bone tissue engineering

Reference	E18597
Principal Investigator / Supervisor	Professor Martin Garnett
Co-Investigators / Co-Supervisors	Professor SM Howdle, Professor Kevin Shakesheff
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	181,280
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	31/07/2006
Duration	40 months

Abstract

We propose a unique multi-disciplinary approach to improve significantly the current technology for gene delivery to stem cells using a non-viral delivery system with a macroscopic controlled release scaffold. The use of macroscopic controlled released scaffolds will provide sustained gene delivery and, critically, functionality, over the entire period of tissue regeneration/repair within defined nanoscale architecture. Gene delivery will be achieved using cationic polymers as non-viral vectors. This combination is achievable through the use of supercritical fluid mixing technology to generate, ultimately, scaffolds encapsulating the gene vehicle and, significantly, functionality of the gene delivery system. The generation of functional bone from this proposal has significant healthcare implications and the generation of non-viral gene delivery and scaffold release technology will have widespread tissue engineering applications (Joint with grant 18596).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E18596 Non-viral gene delivery system for tissue engineering

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