Award details

Optimisation of a new macrophage-based gene therapy for cancer : experimental and mathematical investigations

Reference	E18413/2
Principal Investigator / Supervisor	Professor Markus Owen
Co-Investigators / Co-Supervisors	Professor Helen Byrne
Institution	University of Nottingham
Department	Sch of Mathematical Sciences
Funding type	Research
Value (£)	76,841
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	30/09/2006
Duration	27 months

Abstract

In this project, a synergistic combination of in vitro experiments and mathematical modelling will be used to optimise the efficacy of a novel, macrophage-based gene delivery system. This exploits the tendency of macrophages to migrate into hypoxic regions of tumours to deliver hypoxia-regulated transgenes to such areas. We will determine strategies that optimise macrophage migration into hypoxic areas, gene delivery, and therapeutic impact, by identifying the potential role of: (i) specific macrophage attractants released by tumour cells; (ii) changes in the levels of receptors for these factors expressed by macrophages; (iii) pre-therapy levels of macrophages in hypoxic tumour areas; (iv) bystander effects. (Joint with grant 18414).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E18413 Optimisation of a new macrophage-based gene therapy for cancer : experimental and mathematical investigations

E18414 Optimisation of a new macrophage-based gene therapy for cancer : experimental and mathematical investigations

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