Award details

Development of a non-invasive technique of measuring nitric oxide bioactivity in large arteries in vivo

ReferenceE17208/2
Principal Investigator / Supervisor Professor Peter Weinberg
Co-Investigators /
Co-Supervisors
Dr Martin Carrier
Institution Imperial College London
DepartmentBioengineering
Funding typeResearch
Value (£) 226,281
StatusCompleted
TypeResearch Grant
Start date 01/10/2004
End date 30/09/2007
Duration36 months

Abstract

The nitric oxide (NO) synthesised by blood vessels plays a central role in cardiovascular physiology and pathology, but its bioactivity in vivo is hard to assess. We have recently shown that NO alters the characteristics of the peripheral pulse; this phenomenon promises to form the basis of a simple, novel and non-invasive method of assessment. We will determine whether the phenomenon is as specific to NO as indicated by previous studies, we will characterise the mechanisms underlying it (particularly the role of wave reflections in arteries, using techniques adapted from gas dynamics), and will develop protocols for manipulating NO synthesis in vivo which would allow changes in NO pathway to be characterised. The work, if successful, would have a major impact on cardiovascular research employing experimental animals and could have substantial clinical benefit.

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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