Award details

Development of a non-invasive technique of measuring nitric oxide bioactivity in large arteries in vivo

Reference	E17208
Principal Investigator / Supervisor	Professor Peter Weinberg
Co-Investigators / Co-Supervisors	Dr Martin Carrier
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	334,708
Status	Completed
Type	Research Grant
Start date	09/12/2002
End date	08/10/2004
Duration	22 months

Abstract

The nitric oxide (NO) synthesised by blood vessels plays a central role in cardiovascular physiology and pathology, but its bioactivity in vivo is hard to assess. We have recently shown that NO alters the characteristics of the peripheral pulse; this phenomenon promises to form the basis of a simple, novel and non-invasive method of assessment. We will determine whether the phenomenon is as specific to NO as indicated by previous studies, we will characterise the mechanisms underlying it (particularly the role of wave reflections in arteries, using techniques adapted from gas dynamics), and will develop protocols for manipulating NO synthesis in vivo which would allow changes in NO pathway to be characterised. The work, if successful, would have a major impact on cardiovascular research employing experimental animals and could have substantial clinical benefit.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E17208/2 Development of a non-invasive technique of measuring nitric oxide bioactivity in large arteries in vivo

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