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Templated in situ assembly for the delivery of multi-site ligands
Reference
E15611
Principal Investigator / Supervisor
Professor Christopher Hunter
Co-Investigators /
Co-Supervisors
Professor Jon Waltho
Institution
University of Sheffield
Department
Chemistry
Funding type
Research
Value (£)
166,144
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
30/09/2005
Duration
45 months
Abstract
The aim is to generate high affinity inhibitors by using a protein as a template to assemble dimeric ligands in situ. This approach will facilitate the delivery of high molecular weight multimeric ligands to their site of action. Two strategies will be pursued: connection of the ligands via metal chelate coordination and via disulphide bond formation. We propose to use calmodulin as a model system for the development of general methodology for the delivery of high molecular weight multivalent ligands which self-assemble at their site of action and bind to multiple sites on a biological receptor.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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