Award details

The development of genetic systems to facilitate the exploitation of clostridium genome information

Reference	E13728
Principal Investigator / Supervisor	Professor Peter Mullany
Co-Investigators / Co-Supervisors	Dr Hongmei Wang
Institution	University College London
Department	Eastman Dental Institute
Funding type	Research
Value (£)	199,688
Status	Completed
Type	Research Grant
Start date	01/01/2001
End date	03/05/2004
Duration	40 months

Abstract

Despite their industrial and medical importance, our basic understanding of Clostridium molecular biology and physiology is limited. Genome data for C. acetobutylicum and C. difficile offers new opportunities. However, the genetic systems necessary to manipulate these species are currently inadequate. We propose to develop a Molecular Tool Box to allow the full exploitation of clostridial genome sequences. It is our intention to focus on C. difficile, as the needs are most pressing in this species. However, many of the tools will also be applicable to C. acetobutylicum. Their availability will facilitate programmes of work aimed at deriving a greater understanding of Clostridium sp. molecular biology and physiology. (Joint with grant 346/E13746.)

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E13746 The development of genetic systems to facilitate the exploitation of clostridium genome information

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