Award details

Dioxygenase-catalysed oxidation of organosulphur compounds to yield thiosulphinates and thiophene oxides

Reference	E11506
Principal Investigator / Supervisor	Professor H Dalton
Co-Investigators / Co-Supervisors
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	163,392
Status	Completed
Type	Research Grant
Start date	01/06/1999
End date	01/06/2002
Duration	36 months

Abstract

The chemical synthesis and biotransformation of alkylaryl and dialkyl 1,2-disulfides to yield enantiopure thiosulphinates using dioxygenases (and monooxygenases) will be studied. This asymmetric sulphoxidation study will be complemented by a kinetic resolution approach using racemic thiosuphinate and sulphinate substrates in the presence of sulphoxide reductase enzymes. The synthetic potential of these thiosuphinate and sulphinate enantiomers, will be evaluated with particular emphasis on nucleophilic displacement reactions. The formation of transient thiophene oxides as metabolites, and their potential as in vivo dienophiles to trap diene intermediates (cis-dihydrodiols, triols) will be studied. A comparative study of the formation of thiophene oxides using chemical and enzyme (monooxygenases and dioxygenases) methods, and their synthetic value in the context of polycyclic thiaarene chemistry is proposed. (Joint with grant E11507).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E11507 Dioxygenase-catalysed oxidation of organosulphur compounds to yield thiosulphinates and thiophene oxides

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