Award details

Application of solid-state acid-base buffers to enzyme catalysed reactions in synthetic chemistry

Reference	E10228
Principal Investigator / Supervisor	Professor Nicholas Turner
Co-Investigators / Co-Supervisors	Dr Marie Claire Parker
Institution	University of Edinburgh
Department	Sch of Chemistry
Funding type	Research
Value (£)	51,212
Status	Completed
Type	Research Grant
Start date	24/03/1999
End date	24/03/2002
Duration	36 months

Abstract

This work will develop and exploit methods of controlling and measuring the ionisation state of enzymes in low water media. In particular we will explore the application of newly discovered solid-state acid-base buffering systems in synthetically useful organic phase biotransformations. Potentially these solid buffers can eliminate detrimental changes in enzyme activity or enantioselectivity arising from reactants or products with acid-base properties. This will be tested on reactions leading to biologically active pharmaceutical intermediates such as the dynamic resolution of 5(4H)-oxazolones by lipases and deprotection of phenylacetamides by penicillin amidase. Close collaboration between Strathclyde and Edinburgh will ensure that new insights into the physiochemical control of enzyme catalysed reactions will be rapidly adopted in synthetic applications. (Joint with 78/E10224).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E10224 Application of solid-state acid-base buffers to enzyme catalysed reactions in synthetic chemistry

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