Award details

Application of solid-state acid-base buffers to enzyme catalysed reactions in synthetic chemistry

Reference	E10224
Principal Investigator / Supervisor	Dr Barry Moore
Co-Investigators / Co-Supervisors	Professor Peter James Halling
Institution	University of Strathclyde
Department	Pure and Applied Chemistry
Funding type	Research
Value (£)	165,848
Status	Completed
Type	Research Grant
Start date	01/02/1999
End date	05/03/2002
Duration	37 months

Abstract

This work will develop and exploit methods of controlling and measuring the ionisation state of enzymes in low water media. In particular we will explore the application of newly discovered solid-state acid-base buffering systems in synthetically useful organic phase biotransformations. Potentially these solid buffers can eliminate detrimental changes in enzyme activity or enantioselectivity arising from reactants or products with acid-base properties. This will be tested on reactions leading to biologically active pharmaceutical intermediates such as the dynamic resolution of 5(4H)-oxazolones by lipases and deprotection of phenylacetamides by penicillin amidase. Close collaboration between Strathclyde and Edinburgh will ensure that new insights into the physiochemical control of enzyme catalysed reactions will be rapidly adopted in synthetic applications. (Joint with 15/E10228).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E10228 Application of solid-state acid-base buffers to enzyme catalysed reactions in synthetic chemistry

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