Award details

Functional genomics via the metabolome

Reference	E10149
Principal Investigator / Supervisor	Professor Stephen Oliver
Co-Investigators / Co-Supervisors	Professor Simon James Gaskell
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	178,731
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	30/06/2002
Duration	42 months

Abstract

Using genetically characterised strains of S. cerevisiae grown under controlled conditions, we shall seek the functions of novel genes uncovered in the genome sequencing programme by effecting the quantitative extraction of all the small molecular weight substances in the cells (the metabolome) and use LC-MS, MS-MS and FTIR to effect their discrimination and quantification. We shall exploit advanced chemometric methods to identify those features which are most discriminatory for particular genotypes of interest, and, by comparison with lesions in genes of known function, determine the functions of those presently unknown. (Joint with 2/E10177).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E10177 Functional genomics via the metabolome

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