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Mechanisms underlying survival of Campylobacter jejuni during oxidative and nitrosative stresses (86)

ReferenceD18368
Principal Investigator / Supervisor Dr Simon Park
Co-Investigators /
Co-Supervisors		 Dr Karen Elvers
Institution University of Surrey
DepartmentHealth and Medical Sciences
Funding typeResearch
Value (£) 185,256
StatusCompleted
TypeResearch Grant
Start date 13/11/2002
End date 13/11/2005
Duration36 months

Abstract

Campylobacter jejuni is the major cause of gastrointestinal illness in the UK and USA, but its microaerophilic lifestyle and ability to tolerate oxidative and nitrosative stresses in the food chain remain to be fully understood. We aim to build upon our genome-driven collaborative research and answer the following questions, thereby providing a rational basis for effective control strategies: (1) What are the roles of the putative rubrerythrin- and several hemerythrin-like proteins predicted to be involved in O2 binding and/or managing stress exerted by reactive oxygen species? (2) How does the C. jejuni haemoglobin (Cgb) provide the organism with resistance to nitrosating agents and does it also function in oxygen delivery and/or utilisation? (3) What is the function of a second (truncated) globin in this pathogen in its responses to oxidative and nitrosative stresses? (Joint with grant 18084).

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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