Award details

Mechanisms underlying survival of Campylobacter jejuni during oxidative and nitrosative stresses (86)

Reference	D18084
Principal Investigator / Supervisor	Professor Robert K Poole
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	220,788
Status	Completed
Type	Research Grant
Start date	01/08/2003
End date	30/09/2007
Duration	50 months

Abstract

Campylobacter jejuni is the major cause of gastrointestinal illness in the UK and USA, but its microaerophilic lifestyle and ability to tolerate oxidative and nitrosative stresses in the food chain remain to be fully understood. We aim to build upon our genome-driven collaborative research and answer the following questions, thereby providing a rational basis for effective control strategies: (1) What are the roles of the putative rubrerythrin- and several hemerythrin-like proteins predicted to be involved in O2 binding and or managing stress exerted by reactive oxygen species? (2) How does the C. jejuni haemoglobin (Cgb) provide the organism with resistance to nitrosating agents and does it also function in oxygen delivery and or utilisation? (3) What is the function of a second (truncated) globin in this pathogen in its responses to oxidative and nitrosative stresses? (Joint with grant 18368)

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D18368 Mechanisms underlying survival of Campylobacter jejuni during oxidative and nitrosative stresses (86)

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