Award details

The molecular basis of differential intestinal and placental responses to zinc nutrition

ReferenceD18271
Principal Investigator / Supervisor Professor Dianne Ford
Co-Investigators /
Co-Supervisors
Professor John Mathers
Institution Newcastle University
DepartmentAgriculture Food and Rural Development
Funding typeResearch
Value (£) 240,708
StatusCompleted
TypeResearch Grant
Start date 01/12/2002
End date 31/07/2006
Duration44 months

Abstract

Foetal Zn supply is important for health of the neonate and may influence future susceptibility to a range of non-communicable diseases. We will test the hypothesis that foetal Zn nutrition is regulated through maternal dietary absorption rather than placental delivery via differential activity of transcription factors in placenta and intestine. We will examine regulation by Zn of global gene expression in placental (JAR) and intestinal (Caco-2) cell lines by DNA microarray hybridisation. Key regulatory responses will be confirmed in mouse tissues. We will investigate the role of transcription factors, including MTF-1, by microarray analysis of mRNA from MTF-1 knockout JAR and Caco-2 cells and through use of molecular techniques to examine transcriptional regulation of specific Zn transporters.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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