BBSRC Portfolio Analyser
Award details
The molecular basis of differential intestinal and placental responses to zinc nutrition
Reference
D18271
Principal Investigator / Supervisor
Professor Dianne Ford
Co-Investigators /
Co-Supervisors
Professor John Mathers
Institution
Newcastle University
Department
Agriculture Food and Rural Development
Funding type
Research
Value (£)
240,708
Status
Completed
Type
Research Grant
Start date
01/12/2002
End date
31/07/2006
Duration
44 months
Abstract
Foetal Zn supply is important for health of the neonate and may influence future susceptibility to a range of non-communicable diseases. We will test the hypothesis that foetal Zn nutrition is regulated through maternal dietary absorption rather than placental delivery via differential activity of transcription factors in placenta and intestine. We will examine regulation by Zn of global gene expression in placental (JAR) and intestinal (Caco-2) cell lines by DNA microarray hybridisation. Key regulatory responses will be confirmed in mouse tissues. We will investigate the role of transcription factors, including MTF-1, by microarray analysis of mRNA from MTF-1 knockout JAR and Caco-2 cells and through use of molecular techniques to examine transcriptional regulation of specific Zn transporters.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search