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The expression of the divalent metal transporter (DMT1) in rat colon

ReferenceD17146/2
Principal Investigator / Supervisor Professor Paul Sharp
Co-Investigators /
Co-Supervisors
Institution King's College London
DepartmentSchool of Health and Life Sciences
Funding typeResearch
Value (£) 24,640
StatusCompleted
TypeResearch Grant
Start date 25/02/2005
End date 24/05/2005
Duration3 months

Abstract

The physiological importance of iron to human health is unquestioned. However, in excess iron is highly toxic to cells and tissues. More than 90 per cent of dietary iron passes unabsorbed into the colon where it is available for metabolism by the intralumenal bacteria producing Fe2+ that participates in Fenton reactions producing highly damaging hydroxyl radical adjacent to the colonic mucosa. The overall aim of this proposal is to gain a better understanding of how this metabolically active iron is handled by the colon. Recent preliminary studies in the laboratory have shown that the iron transporter, DMT1, is present in colonic tissue we wish to determine its physiological role in the large intestine. We will test the hypothesis that the spatial distribution of DMT1 and its regulation by the dietary iron load are crucial in determining colonic iron homeostasis.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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