Award details

The expression of the divalent metal transporter (DMT1) in rat colon

Reference	D17146
Principal Investigator / Supervisor	Professor Paul Sharp
Co-Investigators / Co-Supervisors
Institution	University of Surrey
Department	Health and Medical Sciences
Funding type	Research
Value (£)	101,916
Status	Completed
Type	Research Grant
Start date	01/12/2002
End date	31/08/2004
Duration	21 months

Abstract

The physiological importance of iron to human health is unquestioned. However, in excess iron is highly toxic to cells and tissues. More than 90 per cent of dietary iron passes unabsorbed into the colon where it is available for metabolism by the intralumenal bacteria producing Fe2+ that participates in Fenton reactions producing highly damaging hydroxyl radical adjacent to the colonic mucosa. The overall aim of this proposal is to gain a better understanding of how this metabolically active iron is handled by the colon. Recent preliminary studies in the laboratory have shown that the iron transporter, DMT1, is present in colonic tissue we wish to determine its physiological role in the large intestine. We will test the hypothesis that the spatial distribution of DMT1 and its regulation by the dietary iron load are crucial in determining colonic iron homeostasis.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D17146/2 The expression of the divalent metal transporter (DMT1) in rat colon

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