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Mechanism of action of specific isomers of conjugated linoleic acid (CLA) on lipid metabolism: a proteomics approach
Reference
D15685
Principal Investigator / Supervisor
Professor Andrew Salter
Co-Investigators /
Co-Supervisors
Dr Andrew Bennett
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
285,632
Status
Completed
Type
Research Grant
Start date
01/10/2002
End date
28/02/2006
Duration
41 months
Abstract
The term CLA refers to a range of positional and geometric isomers of linoleic acid. Dietary intake of CLAs may be associated with reduction in cancer risk, beneficial changes in lipoprotein concentrations and reduction in adipose tissue deposition. Different CLA isomers have different biological activities. Recent work by us, and others, suggests that some of their effect may be mediated through the PPAR and SREBP classes of transcription factor. These potentially regulate the expression of a wide range of genes that may be associated with the health benefits of CLAs. The aims of this project are to link the effects of specific CLA isomers on transcription factor activity with the expression of proteins that may mediate effects on lipid metabolism.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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